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What is the most tolerated antidepressant? For most patients, sertraline and escitalopram are more effective and better tolerated than other antidepressants. Six medications accounted for 90% of the prescriptions, in the following order: fluoxetine (Prozac) duloxetine (Cymbalta) escitalopram (Lexapro) paroxetine (Paxil) venlafaxine (Effexor) sertraline (Zoloft).
How long do medicine side effects last? The medication effects could be gone even though some medication is still in your blood. Most medications have a half-life of about 24 hours, so they are gone — or close to it — in 4-5 days. A few medications have very long half-lives.
How long does it take to adjust to a new antidepressant? Increase the Dose or Switch? In general, it takes approximately 4 to 6 weeks for antidepressants to work. If you are still experiencing symptoms after this amount of time, talk to your doctor. You may need to increase the dose of your current antidepressant drug or switch to another one altogether.
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